CMT...

*is the most common inherited neuropathy, affecting approximately 125,000 Americans.

*is also known as peroneal muscular atrophy and hereditary motor sensory neuropathy.

*is slowly progressive, causing deterioration of peripheral nerves which control sensory information and muscle function of the foot/lower leg and hand/forearm.

*causes degeneration of peroneal muscles (located on the front of the leg below the knee).

*causes foot-drop walking gait foot bone abnormalities, high arches and hammer toes, problems with balance, problems with hand function occasional lower leg and forearm muscle cramping, loss of some normal reflexes, occasional partial sight and/or hearing loss problems, respiratory problems. Scoliosis (curvature of the spine) is sometimes present.

*does not affect life expectancy.

*has no effective treatment, although physical therapy, occupational therapy and moderate physical activity are beneficial.

*is sometimes surgically treated.

*is usually inherited in an autosomal dominant pattern.

*may become worse if certain neurotoxic drugs are taken.

*can vary greatly in severity, even within the same family.

*can, in rare instances, cause severe disability.

*is the focus of significant genetic research, bringing us closer to answering the CMT enigma.

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